Sappanone A
APC-992
Sappanone A
Cat. No.
APC-992
CAS No.
102067-84-5
MF
C16H12O5
MW
284.26
Sappanone A is an homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor.
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Description
Storage and Shipping
References
Product Name
CAS No.
102067-84-5
MF
C16H12O5
MW
284.26
Specification
98%
Research Area
Anti-inflammatory and antioxidant
Description
Sappanone A is an homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor. Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g Availability: In stock
Storage and Shipping
Store under frozen or refrigerated conditions, keep away from strong light and heat.
References
[1]. Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28(1):328-36.
[2]. Wang YZ, et al. Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L. J Ethnopharmacol. 2023 Mar 25;304:116020.
[3]. Choo YY, et al. Sappanone A inhibits RANKL-induced osteoclastogenesis in BMMs and prevents inflammation-mediated bone loss. Int Immunopharmacol. 2017 Nov;52:230-237.
[4]. Shi X, et al. Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2. Drug Des Devel Ther. 2020 Jan 8;14:61-71.
[5]. Wang Z, et al. Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway. Front Pharmacol. 2022 Aug 16;13:953004.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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